Introduction
Falcikil al is an antimalarial tablet brand by Astemax Biotech Pvt. Ltd., featuring Artemether 80 mg + Lumefantrine 480 mg in a fixed-dose combination.
Composition
Each tablet contains Artemether 80 mg, a fast-acting artemisinin derivative, and Lumefantrine 480 mg, a longer-acting blood schizonticide, in a 1:6 ratio for synergistic action against Plasmodium falciparum.
Uses
It treats uncomplicated malaria, particularly P. falciparum infections, by rapidly reducing parasite load and preventing recrudescence, following WHO-recommended ACT guidelines.
Mechanism
Artemether generates reactive oxygen species in the parasite’s food vacuole to disrupt heme detoxification, while Lumefantrine inhibits beta-hematin formation and nucleic acid/protein synthesis.
