Introduction
ASTEMATE M1 is a sustained-release tablet from Essendon Formulations division of Astemax Biotech, containing glimepiride and metformin for type 2 diabetes management (not type 1, as it’s ineffective there due to lack of insulin production).
Composition and Mechanism
Typically glimepiride 1 mg + metformin 500 mg SR, where glimepiride prompts insulin release from beta cells, and metformin curbs liver glucose output while boosting insulin sensitivity. The SR form ensures steady release for all-day control with fewer GI issues.
Key Uses
Type 2 diabetes as initial combo therapy when diet fails.
Glycemic control in overweight patients, lowering HbA1c effectively.
Prevents complications like neuropathy or cardiovascular risks.
