Introduction
Tolvanil 15 mg is a GMP-certified tablet brand from Astemax Biotech, featuring Tolvaptan 15 mg as a selective vasopressin V2 receptor antagonist for nephrology applications.
Composition
Each film-coated tablet contains Tolvaptan 15 mg, formulated with excipients like lactose monohydrate, microcrystalline cellulose, maize starch, and magnesium stearate for stability and bioavailability, typically packed in alu-mono strips.
Uses
It’s indicated for hyponatremia due to SIADH, heart failure, liver cirrhosis, or autosomal dominant polycystic kidney disease (ADPKD), helping correct low serum sodium while slowing renal cyst growth.
Mechanism
Tolvaptan blocks vasopressin V2 receptors in the kidneys, promoting aquaresis (electrolyte-sparing water excretion) to raise sodium levels safely without affecting potassium
